NightWise® - 30-Night Dose - Bottle Only

NightWise® - 30-Night Dose - Bottle Only

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Two capsules a night for truly restorative sleep. Ingredients in NightWise promote this type of sleep by helping you fall asleep, reduce occasional sleep interruptions and improve sleep duration.

Trusted ingredients in NightWise have been used by millions of people world-wide to help their body meet its individual sleep needs.

Available as a monthly subscription for the most consistent results.

  • Details
  • Proven Ingredients
  • Supplement Facts

Two capsules a night for truly restorative sleep.

  • Fall asleep faster
  • Stay asleep longer
  • Fewer interruptions

Everyone's sleep needs are different, so the number of minutes in REM or Deep Sleep can vary by individual.
The ingredients in NightWise have been clinically studied to help your body to naturally modulate the ratio between REM and Deep sleep to meet your individual needs.

Available as a monthly subscription for the most consistent results.

Our ingredients are a collection of only the most proven and most effective nature has to offer. But ingredients are only as effective as their delivery. Other companies tend to overdose ingredients like melatonin, hoping that the dose will last through the night. NightWise gives you only what you need, when you need it, with lower, more effective doses that are intelligently delivered.

  • Casein Decapeptide
  • Valerian Root
  • Microdose Melatonin
  • Lemon Balm
  • Hops
  • Magnolia
  • Magnesium
  • Tryptophan

Suggested use: Take 2 capsules with water 30 minutes before bedtime nightly.

Serving Size: 2 Capsules, Amount Per Serving: Magnesium (oxide) 50 mg (12% DV), Proprietary Blend: Valerian extract (root), L-Tryptophan, Casein Decapeptide (milk), Hops extract (flower), Magnolia extract (bark), Lemon Balm extract (leaf), Melatonin.

Other ingredients: Hypromellose, ethyl cellulose, carnauba wax, potassium chloride, povidone, triethylcitrate, blue 2, titanium dioxide. Contains milk.

† This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Intelligently Delivered.

The true brilliance of NightWise is our capsules. Made up of three phases of sleep aid, our Intelligent Release Technology actively shepherds your body through a restorative night’s sleep.




Quick-release layer activates
Within minutes, the capsule dissolves, and the quick-release ingredients enter the body. Just the right amounts of Magnesium, L-Tryptophan, Casein Decapeptide and Micro-dose Melatonin guide the mind and body to relax and fall peacefully to sleep.


Control-layer activates
During the next 2—2.5 hours, our bodies don’t need help to get great sleep. So the beads enter a control layer phase, slowly absorbing water until it’s time to release the next round of ingredients.


Burst-release layer activates
Over the next 4 hours, our beads start to burst, releasing just the right amount of Hops, Valerian Root, Lemon Balm, Magnolia and another microdose of Melatonin, ensuring continuous, uninterrupted sleep.

Proven Ingredients.

At Nightwise, we’re proud to say that the ingredients that make up our beads aren’t breakthrough themselves—instead they’re a collection of only the best studied, safest, most effective ingredients that nature has to offer (it’s how we dose and deliver them that sets us apart).

Casein Decapeptide · Valerian Root · Microdose Melatonin · Lemon Balm · Hops · Magnolia · Magnesium · Tryptophan

Casein Decapeptide

Casein decapeptide is a milk-derived protein fraction. Studies suggest it helps modulate stress and improve sleep by:

  • stimulating GABA neurotransmitters
  • reducing anxiety and stress
  • reducing the time to fall asleep


Valerian root extract has been studied for its ability to reduce sleep interruptions and improve sleep duration by:

  • modulating both adenosine and GABA receptors
  • enhancing GABA release and inhibiting GABA uptake
  • gently stimulating 5-HT receptor to improve serotonin signaling

MicroDose Melatonin

As the master hormone regulating sleep, melatonin is essential for good sleep. Studies suggest that supplemental micro dose melatonin helps you:

  • fall asleep faster
  • stay asleep longer
  • promote daytime alertness vs. high-dose melatonin

Lemon Balm

Lemon balm extract has long been revered for its calming and soothing effects. Studies suggest it helps:

  • soothe digestion, which may reduce sleep interruptions
  • reduce stress and promote relaxation, which may help you fall asleep faster


When used with other ingredients, notably valerian and lemon balm, studies suggest that hops helps with difficulties falling asleep and staying asleep through the night by:

  • making adenosine receptors in your brain better able to sense when it is time for you to sleep
  • helping train circadian rhythms to make your sleep patterns more consistent


Magnolia plant has an ancient history in traditional Chinese, Japanese, and Korean medicine, and is used to promote sleep and relaxation. It has been studied for:

  • interacting with cannabinoid receptors that promote relaxation
  • reduce levels of the stress hormone cortisol, which can cause interrupted or restless sleep


Low levels of magnesium can have negative effects on sleep, including:

  • a strong correlation with restless leg syndrome, which can you to wake up
  • disruption of circadian rhythms


An essential amino acid. Studies suggest it helps:

  • Regulate sleep-wake cycles
  • Promote healthy levels of serotonin and melatonin

Ask Us Anything.

But until you do, here are the answers to some of the most frequently asked questions we receive.


NightWise  is the first and only sleep aid designed to work with our bodies' natural sleep rhythms. By providing you with more uninterrupted sleep, NightWise allows your body to naturally modulate the ratio between REM and deep sleep to meet your individual needs. If you've struggled with morning grogginess from over-the-counter sleep aids, or addictive and frustrating side effects of prescription sleep aids, NightWise is right for you. Its combination of the most tested and understood all-natural ingredients inside our Intelligent Release Technology makes it safe, reliable and the ideal way to achieve restorative sleep.


NightWise will start to work the first time you use it. As you learn your own sleep patterns and habits, it will work even better to promote the right sleep environment.


NightWise is safe and non-habit-forming and can be taken nightly or as needed. That said, consistency can create healthier sleep patterns.


Each batch of NightWise is tested for identity and purity so we can be sure that what’s on the label is what’s in the capsules. We use a third-party, independent lab to test each batch to ensure they are deemed safe by regulations.


As with any product that helps your body to sleep, NightWise may cause drowsiness. Do not take NightWise with alcohol or other sedatives.

Find the answers to more questions see our complete FAQ PAGE.

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Colleen M.
United States United States

Too much

It works however, even at only 3mg of Melatonin it left me a bit groggy in the morning. Got between 5-6 hours if sleep.